Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

Alexandra Schosser; Karoline Fuchs; Theresa Scharl; Friedrich Leisch; Ursula Bailer; Siegfried Kasper; Werner Sieghart; Kurt Hornik; Harald N. Aschauer

Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

Alexandra Schosser
, Karoline Fuchs
, Theresa Scharl
, Friedrich Leisch
, Ursula Bailer
, Siegfried Kasper
, Werner Sieghart
, Kurt Hornik
, Harald N. Aschauer

Publikation: Wissenschaftliche Fachzeitschrift › Originalbeitrag in Fachzeitschrift › Begutachtung

Abstract

After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia
and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single
nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was
performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156)
was observed with SNP rs225. In short, we found significant linkage scores most telomeric on
chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

Originalsprache	Englisch
Seiten (von - bis)	501 - 505
Fachzeitschrift	European Neuropsychopharmacology
Jahrgang	17
Ausgabenummer	6-7
Publikationsstatus	Veröffentlicht - 1 Nov. 2007

Zitat

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title = "Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29",

abstract = "After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).",

author = "Alexandra Schosser and Karoline Fuchs and Theresa Scharl and Friedrich Leisch and Ursula Bailer and Siegfried Kasper and Werner Sieghart and Kurt Hornik and Aschauer, \{Harald N.\}",

year = "2007",

month = nov,

day = "1",

language = "English",

volume = "17",

pages = "501 -- 505",

journal = "European Neuropsychopharmacology",

issn = "0924-977X",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

AU - Schosser, Alexandra

AU - Fuchs, Karoline

AU - Scharl, Theresa

AU - Leisch, Friedrich

AU - Bailer, Ursula

AU - Kasper, Siegfried

AU - Sieghart, Werner

AU - Hornik, Kurt

AU - Aschauer, Harald N.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

AB - After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

M3 - Journal article

SN - 0924-977X

VL - 17

SP - 501

EP - 505

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 6-7

ER -