Abstract
Background: Pregnancy associated cardiovascular pathologies have a significant impact on outcome for mother
and child. Bioimpedance cardiography may provide additional outcome-relevant information early in pregnancy
and may also be used as a predictive instrument for pregnancy-associated diseases.
Methods: We performed a prospective longitudinal cohort trial in an outpatient setting and included 242 pregnant
women. Cardiac output and concomitant hemodynamic data were recorded from 11th-13th week of gestation
every 5th week as well as at two occasions post partum employing bioimpedance cardiography.
Results: Cardiac output increased during pregnancy and peaked early in the third trimester. A higher heart rate
and a decreased systemic vascular resistance were accountable for the observed changes. Women who had a
pregnancy-associated disease during a previous pregnancy or developed hypertension or preeclampsia had a
significantly increased cardiac output early in pregnancy. Furthermore, an effect of cardiac output on birthweight
was found in healthy pregnancies and could be confirmed with multiple linear regression analysis.
Conclusions: Cardiovascular adaptation during pregnancy is characterized by distinct pattern described herein.
These may be altered in women at risk for preeclampsia or reduced birthweigth. The assessment of cardiac
parameters by bioimpedance cardiography could be performed at low costs without additional risks.
and child. Bioimpedance cardiography may provide additional outcome-relevant information early in pregnancy
and may also be used as a predictive instrument for pregnancy-associated diseases.
Methods: We performed a prospective longitudinal cohort trial in an outpatient setting and included 242 pregnant
women. Cardiac output and concomitant hemodynamic data were recorded from 11th-13th week of gestation
every 5th week as well as at two occasions post partum employing bioimpedance cardiography.
Results: Cardiac output increased during pregnancy and peaked early in the third trimester. A higher heart rate
and a decreased systemic vascular resistance were accountable for the observed changes. Women who had a
pregnancy-associated disease during a previous pregnancy or developed hypertension or preeclampsia had a
significantly increased cardiac output early in pregnancy. Furthermore, an effect of cardiac output on birthweight
was found in healthy pregnancies and could be confirmed with multiple linear regression analysis.
Conclusions: Cardiovascular adaptation during pregnancy is characterized by distinct pattern described herein.
These may be altered in women at risk for preeclampsia or reduced birthweigth. The assessment of cardiac
parameters by bioimpedance cardiography could be performed at low costs without additional risks.
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 128 - 137 |
| Fachzeitschrift | BMC Pregnancy and Childbirth |
| Jahrgang | 16 |
| Ausgabenummer | 1 |
| DOIs | |
| Publikationsstatus | Veröffentlicht - 2016 |
Österreichische Systematik der Wissenschaftszweige (ÖFOS)
- 101018 Statistik
- 101019 Stochastik