The complexity of cyberattacks in Cyber-Physical Systems (CPSs) calls for a mechanism that can evaluate critical infrastructures’ operational behaviour and security without affecting the operation of live systems. In this regard, Digital Twins (DTs) provide actionable insights through monitoring, simulating, predicting, and optimizing the state of CPSs. Through the use cases, including system testing and training, detecting system misconfigurations, and security testing, DTs strengthen the security of CPSs throughout the product lifecycle. However, such benefits of DTs depend on an assumption about data integrity and security. Data trustworthiness becomes more critical while integrating multiple components among different DTs owned by various stakeholders to provide an aggregated view of the complex physical system. This article envisions a blockchain-based DT framework as Trusted Twins for Securing Cyber-Physical Systems (TTS-CPS). With the automotive industry as a CPS use case, we demonstrate the viability of the TTS-CPS framework through a proof of concept. To utilize reliable system specification data for building the process knowledge of DTs, we ensure the trustworthiness of data-generating sources through Integrity Checking Mechanisms (ICMs). Additionally, Safety and Security (S&S) rules evaluated during simulation are stored and retrieved from the blockchain, thereby establishing more understanding and confidence in the decisions made by the underlying systems. Finally, we perform formal verification of the TTS-CPS.