Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

Alexandra Schosser; Karoline Fuchs; Theresa Scharl; Friedrich Leisch; Ursula Bailer; Siegfried Kasper; Werner Sieghart; Kurt Hornik; Harald N. Aschauer

Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

Alexandra Schosser, Karoline Fuchs, Theresa Scharl, Friedrich Leisch, Ursula Bailer, Siegfried Kasper, Werner Sieghart, Kurt Hornik, Harald N. Aschauer

Publication: Scientific journal › Journal article › peer-review

Abstract

After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia
and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single
nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was
performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156)
was observed with SNP rs225. In short, we found significant linkage scores most telomeric on
chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

Original language	English
Pages (from-to)	501 - 505
Journal	European Neuropsychopharmacology
Volume	17
Issue number	6-7
Publication status	Published - 1 Nov 2007

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@article{f8d821375aab49c390b3b79eb6656f16,

title = "Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29",

abstract = "After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).",

author = "Alexandra Schosser and Karoline Fuchs and Theresa Scharl and Friedrich Leisch and Ursula Bailer and Siegfried Kasper and Werner Sieghart and Kurt Hornik and Aschauer, {Harald N.}",

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pages = "501 -- 505",

journal = "European Neuropsychopharmacology",

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TY - JOUR

T1 - Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

AU - Schosser, Alexandra

AU - Fuchs, Karoline

AU - Scharl, Theresa

AU - Leisch, Friedrich

AU - Bailer, Ursula

AU - Kasper, Siegfried

AU - Sieghart, Werner

AU - Hornik, Kurt

AU - Aschauer, Harald N.

PY - 2007/11/1

Y1 - 2007/11/1

N2 - After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

AB - After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156) was observed with SNP rs225. In short, we found significant linkage scores most telomeric on chromosome 3q29, spanning 3.46 Mbp (7 SNPs).

M3 - Journal article

SN - 0924-977X

VL - 17

SP - 501

EP - 505

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

IS - 6-7

ER -