Additional Support for Linkage of Schizophrenia and Bipolar Disorder to Chromosome 3q29

Alexandra Schosser, Karoline Fuchs, Theresa Scharl, Friedrich Leisch, Ursula Bailer, Siegfried Kasper, Werner Sieghart, Kurt Hornik, Harald N. Aschauer

Publication: Scientific journalJournal articlepeer-review


After publishing a genome scan and follow-up fine mapping, suggesting schizophrenia
and bipolar disorder linkage to chromosome 3q29, we now genotyped 11 additional SNPs (single
nucleotide polymorphisms), in order to narrow down a potential candidate region. Linkage was
performed using the GENEHUNTER program version 2.1r3. A NPL score Zall of 3.891 (p=0.000156)
was observed with SNP rs225. In short, we found significant linkage scores most telomeric on
chromosome 3q29, spanning 3.46 Mbp (7 SNPs).
Original languageEnglish
Pages (from-to)501 - 505
JournalEuropean Neuropsychopharmacology
Issue number6-7
Publication statusPublished - 1 Nov 2007

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