Mixtures of Regression Models for Time-Course Gene Expression Data: Evaluation of Initialization and Random Effects

Theresa Scharl, Bettina Grün, Friedrich Leisch

Publication: Scientific journalJournal articlepeer-review

Abstract

Finite mixture models are routinely applied to time course microarray data. Due to the complexity and size of this type of data, the choice of good starting values plays an important role. So far initialization strategies have only been investigated for data from a mixture of multivariate normal distributions. In this work several initialization procedures are evaluated for mixtures of regression models with and without random effects in an extensive simulation study on different artificial datasets. Finally, these procedures are also applied to a real dataset from Escherichia coli.
Original languageEnglish
Pages (from-to)370 - 377
JournalBioinformatics
Volume26
Issue number3
Publication statusPublished - 1 Apr 2010

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